The following adverse reactions have been reported infrequently with clotrimazole and betamethasone dipropionate when used in combination: paraesthesia, maculopapular rash, edema and secondary infection. Reported adverse reactions to clotrimazole include erythema, stinging, blistering, peeling, edema, pruritus, urticarial and general irritation of the skin. The following local adverse reactions have been reported with the use of topical corticosteroids: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae and miliaria. Hypothalamic - pituitary - adrenal (HPA) axis suppression, Cushing's syndrome and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches and bilateral papilledema.
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